Eight variants were deemed to have a nonsignificant association with COPD risk: TNF-α rs1800610, TGF-β1 rs2241712, rs1982073, and rs6957, IL1β rs1143627, SOD3 rs1799895, ADAM33 rs528557, and VDBP GC-2. This evidence concerns the gene TNF and chronic obstructive pulmonary disease.