Approximately 50% of obese Black patients with new-onset, unprovoked diabetic ketoacidosis (DKA) or severe hyperglycemia (SH) achieve near-normoglycemia remission (defined as fasting blood glucose [FBG] <130 mg/dl, random blood glucose (BG) <180 mg/dl, and HbA1c < 7% while off insulin for at least 1 week) with aggressive insulin treatment (1). The gene discussed is INS; the disease is diabetic ketoacidosis.