In simple Cox regression analysis (Table 2), the baseline clinical and biochemical variables associated with the risk of CKD progression were age, eGFR, UACR >8.44 mg/g, BMI, SBP, DBP, total cholesterol, HDL-C, triglycerides, HbA1c, hemoglobin, statin treatment, and angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) treatment in all patients. The gene discussed is ACE; the disease is chronic kidney disease.