Interactions with the ErbB3 epidermal growth factor receptor (70), the scaffold protein connector enhancer of Ksr (71) and tissue inhibitor of metalloproteinases-3 (72) are implicated in AT2 receptor-mediated antigrowth effects, while interactions with the transcription factor promyelocytic zinc finger protein are involved in the mediation of cardiac hypertrophy (73). The gene discussed is TIMP3; the disease is cardiac hypertrophy.