Our MethylationEPIC BeadChip data validated 7 hypermethylated genes (CYP2D7P1, GFRA1, HDAC4, LIMS2, NAV3, PAX6 and UPK1B), and 10 hypomethylated genes (DPP10, CPLX1, CSMD2, GPR133, NRXN1, PCSK9, PENK, PRDM16, PTPRN2 and TNXB) reported in previous placenta epigenome-wide association studies in GDM (11, 13, 16). The gene discussed is CPLX1; the disease is gestational diabetes.