GO and KEGG pathway analyses showed that inflammation-, immunity-, and infection-associated terms were enriched in db/db mice microglia, such as Il17ra, Il6ra, Cmklr1, Nlrp3, Trem2, Coronavirus disease-COVID-19, Epstein-Barr virus infection, phagosome and NF-κB signaling pathway. The gene discussed is NLRP3; the disease is COVID-19.