IL6 and diabetes mellitus: GO term analysis of the upregulated genes of microglia revealed enrichment of expected biological processes such as immune system process, inflammatory response, cellular response to lipopolysaccharide, defense response to Gram−positive bacterium and positive regulation of interleukin-6 (Figure 6C), and it has also been reported that microglial inflammatory activation, stimulated by diabetes mellitus (DM), which caused memory deficits, gene alterations in brain endothelium (24).