Obesity or increased adiposity plays a key role in endothelial dysfunction by activating several cascades of pathological events, namely activation of renin-angiotensin system (239), activation of procoagulant/hypercoagulation pathway (240), activation of proinflammatory mediators (241), insulin resistance (242), oxidative stress (243), platelet dysfunction (244), and immune dysregulation (245). Here, REN is linked to obesity due to melanocortin 4 receptor deficiency.