In a study comparing the efficacy and safety of insulin glargine 100 U/ml (IGla100) and insulin degludec100 U/ml (IDeg100) in patients with T2DM, the standard deviation (SD) and coefficient of variation (CV) of blood glucose on day 7 were higher in the IDeg100 group, indicative of greater glucose fluctuation (14). This evidence concerns the gene INS and type 2 diabetes mellitus.