(9) observed the occurrence of renal failure in patients with stage 3–5 CKD (approximately 40% with diabetes); they showed that a model adjusted for serum albumin, serum calcium, blood phosphate, and blood bicarbonate well predicts the incidence of ESRD (C-index of 0.917, 95% CI (0.901–0.933)), but this model is difficult to promote in clinical practice because it uses variables not commonly used in daily follow-up. This evidence concerns the gene ALB and kidney failure.