AKT1 and gallbladder cancer: Data obtained with the GBC-SD gallbladder cancer cell line demonstrated that its overexpression can down-regulate cell proliferation and induce apoptosis via stabilization of the phosphatase and tensin homolog (PTEN) and inhibition of the PI3K-Akt pathway, reducing xenograft tumor growth in vivo (Sheng et al., 2019[61]).