SYNE1 and hepatocellular carcinoma: In addition, Sur-Erdem et al. (2020[67]) reported that the giant actin-binding protein nesprin-1 is able to reverse the tumorigenic phenotype of HuH7 hepatocellular carcinoma cells, whereas data from Huang et al. (2016[21]) demonstrated that up-regulation of endoplasmic reticulum resident protein 44 determines the inhibition of human A549 lung cancer cell migration via an inositol 1,4,5-triphosphate receptor‐dependent pathway.