Several signaling pathways are involved in the pathogenesis of sepsis-induced myocardial injury, such as PI3K/AKT, MAPKs, TLR4/MyD88/NF-κB, and gp130/JAK/STAT (Kawai and Akira, 2010; Clere-Jehl et al., 2020). Here, PIK3CA is linked to Sepsis.