PI3Ks generate lipids that controls several signaling pathways (AKT/eNOS, NADPH oxidase, and TGF-β/Smad), which participate in cardiovascular diseases, including myocardial infarction and diabetes-induced cardiomyopathy (Kim et al., 2008; Pretorius et al., 2009; Lin et al., 2010). Here, AKT1 is linked to cardiovascular disorder.