Among 5,607 DEGs, Lrg1, Ace2, Itgb6, Hmgb2, Pik3r5, Itgam, Plcb1, Jak2, Vegfa, and Hif1α were associated with the entire course of sepsis-induced myocardial injury, which have been reported previously (Kumagai et al., 2016; Hashida et al., 2017; Narula et al., 2020). Here, HMGB2 is linked to Sepsis.