Tan IIA efficiently restored redox homeostasis by upregulating NRF2, inhibiting NADPH oxidase 4, and preventing myofibroblast activation by disrupting the protein kinase C-δ/Smad3 pathway, which is ROS-mediated, decreasing extracellular matrix deposition in rats with bleomycin-induced lung fibrosis. This evidence concerns the gene NFE2L2 and pulmonary fibrosis.