ATM and neoplasm: Insights from this work will be relevant to cells carrying mutations in the ATM gene, which are present in many cancers (e.g., in about 45% of lymphomas) (Choi et al., 2016), wherein lack of ATM may promote invasion or intra- and extravasation of tumor cells during the early steps of metastasis (Chaffer and Weinberg, 2011; Davidson et al., 2014).