For example, progeroid Lmna mutations cause ATM-dependent activation of NF-κB signaling and pro-inflammatory cytokine secretion (Osorio et al., 2012), and ATM inhibition in a progeria cell model resulted in increased mitochondrial function, reduced senescence, reduced accumulation of mutant lamin A, and improved nuclear shape (Kuk et al., 2019). This evidence concerns the gene ATM and progeroid syndrome.