NFKB1 and progeroid syndrome: For example, progeroid Lmna mutations cause ATM-dependent activation of NF-κB signaling and pro-inflammatory cytokine secretion (Osorio et al., 2012), and ATM inhibition in a progeria cell model resulted in increased mitochondrial function, reduced senescence, reduced accumulation of mutant lamin A, and improved nuclear shape (Kuk et al., 2019).