Complement C5a receptor 1 (C5aR1)-positive neutrophils secreted IL (Interleukin) 1β and tumor necrosis factor α (TNFα) to synergistically activate ERK1/2, which resulted in phosphorylation of WTAP at serine 341, thereby stabilizing WTAP protein to promote RNA m6A methylation of enolase 1 (ENO1) and affected the glycolysis of breast cancer cells (Ou et al., 2021). This evidence concerns the gene TNF and breast carcinoma.