In all, 252 upregulated EV proteins including apolipoprotein C-III, apolipoprotein D, platelet glycoprotein Ib alpha chain, complement C1q subcomponent subunit A, and complement C5 have been identified after MI using liquid chromatography coupled to tandem mass spectrometry and present an important opportunity for an EV diagnostic panel for the early diagnosis of MI (Cheow et al., 2016). This evidence concerns the gene C5 and myocardial infarction.