NUP98-KDM5A fusion is most frequently found in acute megakaryoblastic leukemia, but it has also been detected in other AML subtypes (Noort et al., 2021) and it is possible that the cell subtype in which the genetic hit takes place determine the resulting AML phenotype, as has been demonstrated for the ETO-GLIS2 fusion protein (Lopez et al., 2019). This evidence concerns the gene KDM5A and acute megakaryoblastic leukemia.