NLRP3 and atrial fibrillation: Inflammation could be one of the most potent AF triggers and the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome myocardial activation, through the production of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18, is associated with the pathogenesis of AF by promoting atrial structural and electrical remodeling (Yao et al., 2018).