TLR4 and hepatocellular carcinoma: Hypoxia-induced ubiquitin-specific peptidase 13 (USP13) deubiquitinated and stabilized toll-like receptor 4 (TLR4) to activate the myeloid differentiation primary response gene 88/nuclear factor-κB (MyD88/NF-κB) pathway, thereby contributing to HCC progression (Gao et al., 2020).