Only ACTA2-AS1 was mapped into the ceRNA network in KIRP, where it established a ceRNA relationship with PPP1R12B. PPP1R12B has been shown to inhibit tumor growth and metastasis by regulating Grb2/PI3K/Akt signaling in colorectal cancer (Ding et al., 2019). This evidence concerns the gene GRB2 and colorectal cancer.