A significant percentage of G2019S LRRK2-PD fibroblasts displayed a kinase-mediated loss of centrosomal CDK5RAP2 as compared to healthy controls (Figures 9B and 9C), which correlated with a modest nonsignificant increase in the levels of phospho-Rab10, without changes in the total levels of CDK5RAP2 as judged by immunoblotting (Figures 9D and 9E). Here, LRRK2 is linked to Parkinson disease.