We here analyzed a total of 12 CLCN4 variants that were associated with X-linked intellectual disability and epilepsy in previous studies, G78S, L221V, V536M, G731R (Hu et al., 2016), D15N, V212G, L221P, V275M, S534L, A551V, R718W (Palmer et al., 2018) and G544R (Veeramah et al., 2013). The gene discussed is CLCN4; the disease is epilepsy.