In kidney diseases, EGR1 was observed in the proximal tubule in response to hypoxic stimuli, and silencing of EGR1 could alleviate the injury in diabetic kidney disease and protect from renal inflammation and fibrosis (Sun et al., 2014; Miyamoto et al., 2016; Hu et al., 2020). The gene discussed is EGR1; the disease is diabetic kidney disease.