Multiple reports have shown that BM adipocytes treated with asparaginase (ASNase) have an adverse effect on leukemia cells, Gln synthase produced by BM fat cells is up-regulated after chemotherapy, Adipocytes inhibit the cytotoxic activity of ASNase by releasing Glutamine into the leukemia microenvironment (Ehsanipour et al., 2013; Parmentier et al., 2015). The gene discussed is ASPG; the disease is leukemia.