Several pieces of evidence demonstrate the multitarget effect of CBD in stroke and/or HI models involving the CB1R, CB2R, GPR55, 5-HT1A, and PPARɣ receptors (Mishima et al., 2005; Castillo et al., 2010; Pazos et al., 2013; Mori et al., 2021). The gene discussed is CNR1; the disease is Stroke.