Moreover, WIN55,212-2 was also able to increase the number of NG2+-OPCs within the stroke penumbra and reduce the NG2+/caspase-3+ cells during 14 days post-damage in a pMCAO model, an effect that could be related to the increased expression of CB1R in that area (Sun and Fang, 2013). The gene discussed is CNR1; the disease is stroke disorder.