To further corroborate the functional association between ASD and eCB signaling, and in line with the dysregulation of 2-AG metabolism found in different animal models of FXS (Maccarrone et al., 2010a; Jung et al., 2012), also the use of neurodevelopmental models of autism such as the prenatal exposure to valproic acid (VPA) has provided evidence for reduced DAGL-α activity in the cerebellum and concomitant increase of MAGL-dependent 2-AG degradation in the hippocampus (Kerr et al., 2013). Here, MGLL is linked to autism.