Besides the effects of CBD in the Shank3 mouse model of autism (Poleg et al., 2021), and the ASD-like neurophatological phenotype and deficits in social behavior described in models of prenatal exposure to VPA, in BTBR (Kratsman et al., 2016) and in FXS fmr1 KO mice (Kazdoba et al., 2016), there is another link between mutations in Synapsin (SYN) genes and patients with comorbid ASD and epilepsy that is worth exploring (Fassio et al., 2011). Here, FMR1 is linked to autism.