FMR1 and autism: Of note, striatal levels of 2-AG were not found changed in FMRP KO mice but an increased activity of the enzyme responsible for 2-AG degradation (i.e., MAGL) was instead observed, thus suggesting a decrease of 2-AG tone/signaling in a brain region whose function is considered of key importance for autism pathophysiology (Fuccillo, 2016).