This ability may be of key importance for the GPR119-mediated intestinal secretion of the incretin hormone glucagon-like peptide-1 (GLP-1), and therefore for the maintenance of insulin secretion/sensitivity and appetite suppression not only in metabolic pathology such as diabetes and obesity but also in neurodegenerative disorders (Brown et al., 2018; Müller et al., 2019). Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.