FMR1 and fragile X syndrome: More recently, a couple of studies showed that the increase of AEA signaling via pharmacological FAAH inhibition can counteract either social deficit (Wei et al., 2016) or aversive memory (Qin et al., 2015), not only in FXS animal model (i.e., fmr1/FMRP KO mouse), but also induce an improvement of social impairment in the BTBR mouse model of ASD-like behavior (Wei et al., 2016).