The mutual connections between RAS-genes (i.e. ACE1/ACE2) and TP53/NFKB1 genes, and the observation that, as described for ACE1 and ACE2 gene variants, the frequencies of R72/P72-allele of TP53 gene strongly vary among different ethnicities correlating with SARS-CoV2 mortality/infection rates, open promising pharmacogenomics approaches for COVID-19 and others emerging virus-related diseases. The gene discussed is ACE2; the disease is COVID-19.