Moreover, the experience coming from tumor biology suggests that NF-κB activation counterbalance the pro-apoptotic activity of p53 by affecting p53 viability through MDM2 induction (Luo et al., 2005), in line with the similarities between tumorigenesis process and those related to viral infection and host-virus interaction (Mehta et al., 2021). This evidence concerns the gene TP53 and neoplasm.