In addition, considering RAS pathway over-activation as one of the main causes in determining COVID-19 severity, is in line with the recently GWAS identified associations of ABO and SLC6A20 loci (Severe Covid-19 GWAS Group, 2020), being crucial modifiers of local Ang-II levels and water/salt reabsorption (Chung et al., 2010; Terao et al., 2013; Gasso et al., 2014; Ling et al., 2014; Vuille-dit-Bille et al., 2015; Gemmati et al., 2020). The gene discussed is ABO; the disease is COVID-19.