Moreover, and in the LPS-induced depression model in mice, the H3R antagonist/inverse agonist JNJ-10181457 was found to exhibit antidepressant-like effects by reducing the immobility time of tested mice in the tail suspension test, with evidenced reducing effects on the release of proinflammatory cytokines from microglial cells (Iida et al., 2017). This evidence concerns the gene HRH3 and depressive symptom measurement.