HRH3 and Cognitive impairment: Likewise, and in a Y-maze task, the H3R antagonist/inverse agonist SAR110894 reversed cognitive impairment associated with schizophrenia and attention-deficit/hyperactivity disorder, and improved memory performances in several variants of the object recognition task in mice or rats (0.3–1 mg/kg, p.o.)(Griebel et al., 2012).