In previous studies, plant flavonoids and terpenoids were widely used in prevention of obesity and diabetes by ameliorating insulin resistance, specifically, by activating AMPK and PI3K/AKT signaling (Ding et al., 2012; Zhang et al., 2012; Paoli et al., 2013; Rodríguez-Rodríguez et al., 2015). Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.