For example, Jia et al. (2014) observed that emodin could reduce the secretion of TNF-α, IL-1β, and IL-6, inhibit the expression of leukocyte chemokine CCL2, improve the inflammatory response in HFD mice and suppress the transition from simple steatosis to NASH . This evidence concerns the gene CCL2 and metabolic dysfunction-associated steatohepatitis.