Yan et al. (2017) suggested that the chloroform extract of HDW(CEHDW) may play an anticancer role by suppressing phosphorylation of PI3K/AKT and RAS/ERK signaling pathways: CEHDW could inhibit proliferation and promote apoptosis of the SW620 CRC cell lines, and in addition, it plays this role by decreasing the expression levels of B-cell lymphoma 2(Bcl-2), cyclin D1, cyclin-dependent kinase 4(CDK4), surviving and proliferating cell nuclear antigen (PCNA), and increasing the expression levels of Bcl-2-associated X (Bax) protein. The gene discussed is CDK4; the disease is colorectal carcinoma.