TP53 and colorectal carcinoma: Feng et al. (2017) further confirmed that EEHDW has strong anti-colorectal cancer activity both in vivo and in vitro, and also built a CMX model and some human CRC cell lines (HCT-8, HT-29, HCT-116, and SW620 cells). The results show that EEHDW could regulate various inflammatory (IL-1β, IL-6, IL-4, IL-10, TNF-α) and angiogenic factors (COX-2, iNOS, eNOS, HIF-1α) and downregulate the expression of various oncogenes (Bcl-2, Bax, Pim-1, p53), thus affecting the proliferation and apoptosis of cancer cells and tumor angiogenesis.