AKT1 and cancer: Li et al. (2019) constructed a human lymphatic endothelial cell (HLEC) model stimulated by vascular endothelial growth factor C (VEGF-C) and found that EEHDW regulates PI3K/AKT, ERK, and signal transducer and activator of transcription 3(STAT3) signaling pathways to inhibit VEGF-C-mediated lymphatic formation of HCT-116 and HCT-8 cell lines, thus blocking the migration of cancer cells and lymphangiogenesis.