STAT3 and neoplasm: Triterpenes are essential for human health; they could suppress nuclear factor kappa B (NF-κB), STAT3, nuclear factor erythroid-2-related factor 2 (Nrf2), and other key signaling pathways to activate the antioxidant and anti-inflammatory ability, cell cycle regulation, and epigenetic to prevent tumor development (Li S et al., 2020).