Sun et al. (2016) showed that HDW may inhibit CRC stem cells; EEHDW can significantly reduce the expression of Lgr5, PCNA, ABCB1, survivin, β-catenin, and c-Myc in HT-29 SP cells and reduce the proportion of SP in HT-29 cells. These are associated with the inhibition of the Wnt/β-catenin signaling pathway and the expression of ABC transporters. Both Lai et al. (2017) and Chen et al. (2018) found that EEHDW inhibited metastasis of HCT-8/5-FU cells by regulating the transforming growth factor-β (TGF-β) signaling pathway, which showed inhibition of cell adhesion, migration, and invasion. Here, PCNA is linked to colorectal carcinoma.