BDNF and Alzheimer disease: Chen et al. has also reported that α7nAChR blockade could inhibit the reverse of hippocampal BDNF and abolish the neuroprotective effects of simvastatin in Aβ25-35-mice, an inhibitor of 3-hydroxy-3-methyl-glytarylcoenzyme reductase, which is effective in improving cognition in AD patients (Wang et al., 2015).