Although MCL is characterized by the aberrant expression of cyclin D1 (Swerdlow et al., 2016), neither ganetespib nor ibrutinib showed obvious effects on cyclin D1 expression in either cell lines and there was not a consistent trend in the expression levels of Cyclin D1 after drug treatments in this study (Figures 2E,F). Here, CCND1 is linked to mantle cell lymphoma.