Previous studies suggested that JAK-STAT, IL-17, and p53 signaling pathways were not only closely associated with the tumorigenesis of NSCLC via regulating cell proliferation, differentiation, and apoptosis but also involved in the promotion of cytokine storm which deteriorated conditions in COVID-19 patients (Shibabaw, 2020; Hu H. et al., 2021; Satarker et al., 2021). Here, TP53 is linked to non-small cell lung carcinoma.