Meanwhile, the herbs could reduce Bcl-2 expression and enhance the Bax protein level, with a ratio of Bax/Bcl-2 significantly increased in a dose-dependent manner (Figures 6C,D), and the “cocktail” groups had better effects, especially (AMD IC0+RTD IC50) and (AMD IC25 + RTD IC50). Here, BCL2 is linked to age-related macular degeneration.