Based on the aforementioned theories and previous studies, this study applied a holistic animal and cellular model, employing a type I diabetic rat model and cultured renal tubular epithelial cells (NRK-52E) with high glucose as the study subjects, and used gene therapy with the overexpression of BMP-7 adeno-associated virus, OMT, MAPK pathway inhibitors, and other multi-method interventions to investigate the effects of BMP-7 on downstream fibrogenic-related signaling pathways and OMT. The gene discussed is BMP7; the disease is type 1 diabetes mellitus.