NR1H3 and dry age related macular degeneration: In parallel, others demonstrated that in the retina or RPE, LXR expression is decreased in diabetic retinopathy and dry AMD and could contribute to lipid dysregulation in both diseases, possibly via LXRα in the latter (Hazra et al., 2012; Hammer et al., 2017; Choudhary et al., 2020).