Vimentin (an intermediate filament protein) is a marker of mesenchymal-derived cells (e.g., fibroblasts and endothelial cells) as well as cells undergoing epithelial-mesenchymal or endothelial-mesenchymal transitions (Liu et al., 2015; Evrard et al., 2016; Piera-Velazquez and Jimenez, 2019), which play key roles in the pathogenesis of subretinal fibrosis, the end-stage of AMD (Shu et al., 2020). The gene discussed is VIM; the disease is age-related macular degeneration.