Up-regulated expression of extracellular matrix (ECM) components TGF-β1, connective tissue growth factor (CTGF), fibroblastic growth factor (bFGF), and collagen I was observed in patients with hepatic fibrosis, accompanied by changes in lipid metabolism, amino acid metabolism, purine metabolism, and taurine metabolism (Bianchi et al., 2000; Zhang et al., 2006; Zhao et al., 2014). Here, CCN2 is linked to Hepatic fibrosis.