STAT3 and neoplasm: The combination treatment effectively delayed tumor growth and blocked EGFR by decreasing the phosphorylation of STAT3, p38 MAPK, ERK1/2, and BAD proteins, while the IC50 value of CHE was between HCC827 (IC50=5.0 ± 0.48 μM), SK-MES-1 (IC50=6.35 ± 1.26 μM), and A459 (IC50=7.78 ± 0.56 μM) (He et al., 2017).