SOX2 and lung carcinoma: In addition, an in vivo study proved that CHE exerted specific anticancer effects on concentration adjustment to inhibit the Wnt/β-catenin pathway in different lung cancers and facilitate cancer cell apoptosis, inhibiting the proliferation and diminishing the self-renewal capacity of human lung cancer stem cells (HLCSCs) by downregulating β-catenin, SOX2, and MYC (Heng and Cheah, 2020; Wang et al., 2021).