Another study on human renal cancer cell lines (SW-839) showed that CHE could inhibit the proliferation and growth of renal cancer cells in a time- and dose-dependent manner by decreasing the phosphorylation of ERK and Akt, upregulating p53 and Bcl-2, and cleaving caspase-3 and PARP protein. Here, CASP3 is linked to renal carcinoma.