Aberrant activation of the NLRP3 inflammasome is also involved in the development of several neurodegenerative disorders, such as PD, Alzheimer’s disease (AD), and multiple sclerosis (Heneka et al., 2013; Haque et al., 2020; Malhotra et al., 2020). The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.