Increasing evidence indicates that the activation of the NF-κB pathway and the NLRP3 inflammasome is widely involved in different diseases, such as colitis, diabetes, and COVID-19 infection-induced pneumonia in the peripheral tissue (Wang et al., 2018; An et al., 2019; Xian et al., 2021). The gene discussed is NFKB1; the disease is susceptibility to pneumonia measurement.