XPO1 and cancer: Therefore, XPO1 is considered an effective target for the treatment of cancer, inflammation, and autoimmune diseases, through the regulation of nuclear–cytoplasmic localization of important proteins (Mao and Yang, 2013; Gravina et al., 2014; Haines et al., 2015; Olazagoitia-Garmendia et al., 2021).