NR3C2 and congestive heart failure: According to 2021 Guidelines for Rational Drug Use at Primary Level in Chronic Heart Failure published by the Chinese Journal of General Practitioners, the indication for digitalis drugs is patients with heart failure (HFrEF) who continue to have persistently decreased ejection fraction after using diuretics, angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARB), β-blockers, and aldosterone receptor antagonists (Guidelines for rational drug use at primary level in chronic heart failure, 2021).