Second, digoxin inhibits Th17 cell differentiation by decreasing the expression of retinoic acid receptor-related orphan receptor γT (ROR-γT) and down-regulating the expression of IL-1β, IL-6, IL-17, and IL-23 in RA patients’ PBMCs (Saeed et al., 2020). The gene discussed is IL6; the disease is rheumatoid arthritis.