Saeed H et al. found that digoxin is closely related to cytokine expression in peripheral blood mononuclear cells (PBMCs) of RA patients, and digoxin can significantly reduce cytokines such as IL-1β, IL-6, and IL-17, among which the effect was most prominent against IL-6 (Saeed et al., 2020). This evidence concerns the gene IL6 and rheumatoid arthritis.