It has been found that CTS can participate in the regulation of key immune cells in the pathological development of Rheumatoid arthritis (RA), atherosclerosis (AS), airway inflammation, and neuroinflammation (Shi et al., 2016; Zeitlin et al., 2017; Saeed et al., 2020; Jansson et al., 2021). This evidence concerns the gene TTR and rheumatoid arthritis.