Recently, The NOD-like receptor protein 3 (NLRP3) inflammasome, an intracytoplasmic multiprotein complex, containing NLRP3, apoptosis-associated speck-like protein (ASC) and procaspase-1, has been confirmed to participate in mediating the inflammatory damage process of ALI (Wu et al., 2013; Grailer et al., 2014). Here, NLRP3 is linked to acute respiratory distress syndrome.