IL-1β and IL-18, as important promoters of inflammation, possess great potential to recruit immune cells like neutrophils and accelerate the release of other inflammatory mediators such as TNF-α and IL-6, triggering inflammation cascades to amplify the inflammatory response significantly during the course of AP (Ma et al., 2012; Bunbupha et al., 2015). The gene discussed is TNF; the disease is alkaline phosphatase measurement.