In disease research, Caitlin E Monaghan et al. found that homozygous mutations in CLP1 can affect the processing of mRNA 3′and ultimately lead to neurodegenerative disease, namely pontocerebellar hypoplasia type 10 (Monaghan et al., 2021); while Kitti Szoták-Ajtay et al. found that CLP1 knockout mice have abnormal lung expansion function, and Clp1 K/K embryos in late pregnancy showed impaired prenatal lymphatic function and impaired lung expansion (Szoták-Ajtay et al., 2020). This evidence concerns the gene CLP1 and neurodegenerative disease.