Comparing RA samples and normal tissue samples, we found that the average infiltration levels of dendritic cells resting, mast cells, T cells CD4 memory resting, Tregs and other cells in RA tissues were significantly lower than those in the healthy group, while M0/M1 macrophages, plasma cells, CD8 T cells, T cells follicular helper and T cells gamma delta were significantly higher than normal samples (Figure 4B–W) using the Wilcox. This evidence concerns the gene CD4 and rheumatoid arthritis.