In PARADIGM-HF (Prospective Comparison of ARNI with ACE inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure) study, sacubitril-valsartan led to significantly lower all-cause and cardiovascular mortality of heart failure with reduced ejection fraction (HFrEF) compared to enalapril alone (6). The gene discussed is ACE; the disease is heart failure.