Comparison of patients with DLE and SCLE using Ingenuity Pathway Analysis revealed pathways associated with fibrotic processes, and longitudinal microarray analysis of patients with DLE and SCLE revealed sustained elevations of TGF-B1, TGF-BR1, SMAD3, MMP1, MMP9, and SERPINE1 (42). The gene discussed is SERPINE1; the disease is discoid lupus erythematosus.