In summary, numerous genes were found to have SNPs that were associated with a greater risk of CLE and SLE, such as TLR7, TRAF3IP2, TYK2, IRF5, IL10, C1QA, and STAT4 (11, 23, 24, 27–29). The gene discussed is TRAF3IP2; the disease is systemic lupus erythematosus.