Our current result on an elevation in protein glutarylation in the animal brain affected by severe SCI, adds to results from independent studies on enhanced abundance of this modification in different pathologies, e.g., in patients with acute myocardial infarction (68), or upon impaired function of deglutarylase sirtuin 5 (69, 70), the enzyme known to be neuroprotective (25, 26). Here, SIRT5 is linked to myocardial infarction.