TNF and COVID-19: Moreover, high concentrations of the same proinflammatory proteins found in the "cytokine storm" associated with COVID-19, including TNF-α, interleukin (IL)-1α, IL-1β, IL-6, and ferritin, also induce skin depigmentation or hypopigmentation by interfering with tyrosinase synthesis, the enzyme that catalyzes the rate-limiting step of pigmentation.