The present study identified a signature involving eight SRGs, BCL6 transcription repressor (BCL6), mitogen-activated protein kinase 8 (MAPK8), mitogen-activated protein kinase 9 (MAPK9), MAPK activated protein kinase 5 (MAPKAPK5), NIMA related kinase 4 (NEK4), pro-apoptotic WT1 regulator (PAWR), Wnt family member 16 (WNT16), and yippee like 3 (YPEL3), predictive of the prognosis of CRC. Here, NEK4 is linked to colorectal carcinoma.