IL6 and obesity due to melanocortin 4 receptor deficiency: Inflammatory factors such as interleukin 6 (IL-6), TNF-α, and monocyte chemoattractant protein-1 (MCP-1), underly chronic the low-grade systemic proinflammatory state correlated with age-associated diseases such as hypertension, obesity, and diabetes (Franceschi and Campisi, 2014).