Moreover, emerging data from human and animal models of PD have reported that α-synuclein has an important role in the control of neuronal mitochondrial dynamic processes (Banerjee et al., 2010; Melo et al., 2018), suggesting a strong candidate for a pathogenic mechanism underpinning PD pathogenesis beyond mitochondrial biogenesis, a well-known factor. This evidence concerns the gene SNCA and Parkinson disease.