LEP and Insulin resistance: In addition, glycolipid metabolism phenotype of the recipient ZDF rats showed significant changes in response to transplantation, as shown in oral glucose tolerance test (OGTT)/insulin secretion test (ITT), glycosylated hemoglobin (HbA1c%), fasting serum insulin (FSI), insulin resistance index (HOMA-IR), leptin and blood biochemistry index levels (TG, TC, and LDL-C), compared with the Z-P group (Figures 2D–L).