Zucker Diabetic Fatty (ZDF) rat is an obese rat model with leptin receptor deficiency and animals of this strain become a stable T2DM model at 9 weeks of age, exhibiting increased blood glucose levels when maintained on an induction diet LabDiet 5008 (Yin et al., 2018; Zhou et al., 2019). The gene discussed is LEP; the disease is type 2 diabetes mellitus.