Among them, insoluble Aβ fibers have neurotoxicity, which changes neuronal ion channels, causing disturbances in the neuron internal environment, accelerating the phosphorylation of Tau protein, and leading to neurofibrillary tangles; while soluble Aβ is more toxic than its fibrous deposits formed later, which affects synaptic function and may be the basis for early cognitive deficits. Here, MAPT is linked to Cognitive impairment.